Laboratory Information معلومات مخبرية

🛑 Morphological Abnormalaties Of Neutrophil ⁉


These conditions include the more ‼frequently observed disorders of:?


♦ toxic granulation

♦ Döhle bodies

♦ hypersegmentation



⭕⭕ as well as rarely observed disorders such

♦Pelger-Huët
anomaly

♦May-Hegglin anomaly

♦ Chédiak-Higashi syndrome

♦ Alder-Reilly inclusions.

🛑Hypersegmentation

⭕Hypersegmentation is most frequently seen in
neutrophils with more than five lobes or nuclear segments ..

⭕This condition is frequently associated with defiecencies of
vitamin B12 or folic acid .

⭕Pseudohyprer segmentation may be seen in old segmented neutrophils.


🛑Toxic Granulation

This is a condition in which prominent dark granulation‼
either fine or heavy ..

♦can be observed in band and segmented
neutrophils or monocytes ‼⁉Toxic granules are
azurophilic (primary) granules that are peroxidase-positive.

♦The granulation may represent the precipitation of ribosomalprotein (RNA) caused by metabolic toxicity within the cells.

♦. This condition
seen in many conditions such as ‼burns ..and non malignant disorders ..or
as the result of drug therapy.


🛑Döhle Bodies

These inclusion bodies are seen as single or multiple, light-
blue–staining inclusions on Wright-stained blood smears
.
⭕They are usually seen near the periphery of the
cytoplasm.

⭕These inclusions are predominantly seen in
neutrophils although they may be seen in monocytes.

⭕Döhle bodies represent aggregates of roughendoplasmic reticulum (RNA).

⭕may be associated with ❓
viral infections...burns...
certain drugs.



🛑Pelger-Huët Anomaly

♦This is genetically acquired autosomal dominant disorder pro-
duces‼ hyposegmentation of many of the mature neutrophils ..

♦ The nuclear shape may resemble dumbbell ‼or pair of eyeglasses. Although the segments fail to lobulate normally .

♦.pseudoanomaly may be ‼drug induced or may occur in acute infections. .The function
of the cell is considered to be normal despite the morphological abnormal.

@labinformation7

🛑May-Hegglin Anomaly

♦This genetic condition is characterized by the presence of Döhle body–like inclusions in neutrophils eosinophil and monocytes ..

♦Abnormally large and poorly granulated platelets ‼‼and thrombocytopenia frequently coexist in this condition. .

♦ approximately 50% of patients do not ‼have
symptoms others have manifested ‼abnormal bleeding tendencies..

♦The cause of the hemostatic defect is unclear, but it proportionate to the degree of thrombocytopenia.


🛑Chédiak-Higashi Syndrome

♦♦ rare disorder is a hereditary disease‼ autosomal recessive trait


♦It is primarily seen in children and young adults ..

♦is characterized by very large granules These peroxidase positive ‼deposits represent abnormal
lysosomal development in neutrophils and other leukocytes..


♦Neutrophils display
impaired chemotaxis and delayed killing of‼‼ ingested bacteria..

♦Patients with this disorder suffer from frequent infections which suggest that neutrophils with this defect are not efficient bacteriocidal cell..




🛑Chédiak-Higashi Syndrome

⭕⭕rare disorder is a hereditary disease‼ autosomal recessive trait


⭕It is primarily seen in children and young adults ..

⭕is characterized by very large granules These peroxidase positive ‼deposits represent abnormal
lysosomal development in neutrophils and other leukocytes..


⭕Neutrophils display
impaired chemotaxis and delayed killing of‼‼ ingested bacteria..

⭕Patients with this disorder suffer from frequent infections which suggest that neutrophils with this defect are not efficient bacteriocidal cell ..


🛑Alder-Reilly Inclusions


♦purple-red particles are precipitated ‼‼ mucopolysaccharide seen primarily in?? neutrophil

@labinformation7

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🛑 Morphological Abnormalaties Of Neutrophil ⁉


These conditions include the more ‼frequently observed disorders of:?


♦ toxic granulation

♦ Döhle bodies

♦ hypersegmentation



⭕⭕ as well as rarely observed disorders such

♦Pelger-Huët
anomaly

♦May-Hegglin anomaly

♦ Chédiak-Higashi syndrome

♦ Alder-Reilly inclusions.

🛑Hypersegmentation

⭕Hypersegmentation is most frequently seen in
neutrophils with more than five lobes or nuclear segments ..

⭕This condition is frequently associated with defiecencies of
vitamin B12 or folic acid .

⭕Pseudohyprer segmentation may be seen in old segmented neutrophils.


🛑Toxic Granulation

This is a condition in which prominent dark granulation‼
either fine or heavy ..

♦can be observed in band and segmented
neutrophils or monocytes ‼⁉Toxic granules are
azurophilic (primary) granules that are peroxidase-positive.

♦The granulation may represent the precipitation of ribosomalprotein (RNA) caused by metabolic toxicity within the cells.

♦. This condition
seen in many conditions such as ‼burns ..and non malignant disorders ..or
as the result of drug therapy.


🛑Döhle Bodies

These inclusion bodies are seen as single or multiple, light-
blue–staining inclusions on Wright-stained blood smears
.
⭕They are usually seen near the periphery of the
cytoplasm.

⭕These inclusions are predominantly seen in
neutrophils although they may be seen in monocytes.

⭕Döhle bodies represent aggregates of roughendoplasmic reticulum (RNA).

⭕may be associated with ❓
viral infections...burns...
certain drugs.



🛑Pelger-Huët Anomaly

♦This is genetically acquired autosomal dominant disorder pro-
duces‼ hyposegmentation of many of the mature neutrophils ..

♦ The nuclear shape may resemble dumbbell ‼or pair of eyeglasses. Although the segments fail to lobulate normally .

♦.pseudoanomaly may be ‼drug induced or may occur in acute infections. .The function
of the cell is considered to be normal despite the morphological abnormal.

@labinformation7

🛑May-Hegglin Anomaly

♦This genetic condition is characterized by the presence of Döhle body–like inclusions in neutrophils eosinophil and monocytes ..

♦Abnormally large and poorly granulated platelets ‼‼and thrombocytopenia frequently coexist in this condition. .

♦ approximately 50% of patients do not ‼have
symptoms others have manifested ‼abnormal bleeding tendencies..

♦The cause of the hemostatic defect is unclear, but it proportionate to the degree of thrombocytopenia.


🛑Chédiak-Higashi Syndrome

♦♦ rare disorder is a hereditary disease‼ autosomal recessive trait


♦It is primarily seen in children and young adults ..

♦is characterized by very large granules These peroxidase positive ‼deposits represent abnormal
lysosomal development in neutrophils and other leukocytes..


♦Neutrophils display
impaired chemotaxis and delayed killing of‼‼ ingested bacteria..

♦Patients with this disorder suffer from frequent infections which suggest that neutrophils with this defect are not efficient bacteriocidal cell..




🛑Chédiak-Higashi Syndrome

⭕⭕rare disorder is a hereditary disease‼ autosomal recessive trait


⭕It is primarily seen in children and young adults ..

⭕is characterized by very large granules These peroxidase positive ‼deposits represent abnormal
lysosomal development in neutrophils and other leukocytes..


⭕Neutrophils display
impaired chemotaxis and delayed killing of‼‼ ingested bacteria..

⭕Patients with this disorder suffer from frequent infections which suggest that neutrophils with this defect are not efficient bacteriocidal cell ..


🛑Alder-Reilly Inclusions


♦purple-red particles are precipitated ‼‼ mucopolysaccharide seen primarily in?? neutrophil

@labinformation7

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